Hypogonadism is defined as the inability to produce or maintain testosterone levels. The male gonads (testes) are the primary source of production of testosterone. Testosterone is produced in the Leydig cells in the testes under the influence of Luteinizing Hormone (LH). Testosterone gradually decline with age, typically after 40 years. The rate of decline is about 100ng/dl. The lack of testosterone can lead to symptoms such as lethargy, loss of libido, memory changes and mood changes. The long-term effects of hypogonadism can include osteoporosis and possible increase risks for dementia and cardiac problems. The term andropause refers to the hypogonadal status of aging males. The gradual nature of decline in testosterone with age results in an alternative term- androgen decline in aging males (A.D.A.M). Testosterone is the most potent androgen; other androgens include androstenedione and DHEA, DHEA-S. The other less potent androgens also decline with age, also contributing to andropause or the A.D.A.M.
Epidemiological surveys suggest that the prevalence of hypogonadism is about 35% in the above 65-year group. Care must be used in interpreting this data as chronic illness may also depress testosterone levels. Moreover, it is thought that the bioavailable testosterone is responsible for the clinical effects of testosterone. Free testosterone approximates bioavailable testosterone as it is calculated from total testosterone. The affinity of sex hormone binding globulin (SHBG) to testosterone increases with age, leaving less bioavailable testosterone.
The decline in testosterone is not uniform with all populations. In a multinational study using a cross sectional design, it was found that Americans have the steepest decline in free testosterone levels despite the fact that they have the highest levels to start off with. The declines were less with an African population in (Kenya). Nepalese in Asia had a less steep decline compared to Africans. A South American population in Paraguay demonstrated the least decline with age, despite having the lowest levels to start off with. The differences in levels in the different cultures may have implications. Diet, stress and exercise can influence the rate of decline in testosterone levels.
If you have aging related problems and think it is related to the decline in testosterone, seek out the experts at Opal Medical Clinic in Houston. Our web site is at www.opalmedical.com
I don’t have age related low testosterone. My current level of testosterone is 20. It is estimated (a guess) that somewhere around the age of 16 the levels may have dropped. I am now 42 years old. Just discovered 2 years ago about my levels. I try taking the shots, but the side effects almost aren’t worth it. My testicles are about the size of a pencil eraser.
Have you run across this before?